Research Team:  Benson, Catalona, Chatterton, Chiu, Gapstur, Kaklamani, Kamp, Locker, Pasche, Rubenstein

Members of this group are conducting research to better understand the role of genes, cytogenetic alterations, hormones, obesity, diet and lifestyle, and environmental factors involved in cancer risk. The primary focus of these studies is on breast, prostate, and colon cancer, and on non-Hodgkin lymphoma (NHL), with additional studies being conducted on lung cancer. This work involves a variety of approaches, including conventional and molecular epidemiological methods to study intermediate endpoints in multi-ethnic populations (Gapstur), established cohorts (Gapstur, Chiu), case-control studies (Chiu, Pasche, Kaklamani), or in high-risk individuals (Benson, Pasche, Kaklamani, Locker, Rubenstein, Catalona). Other ongoing research includes longitudinal analyses of genetic and lifestyle determinants of hormone profiles (Gapstur), analyses of the effects of dietary and reproductive factors on biomarker levels in novel media such as saliva, breast and nipple aspirate fluid (Chatterton), and mechanistic studies to provide insight into the biologic mechanisms underlying the effects of asbestos exposure on lung pathophysiology. The long-term goal is to open new avenues for primary prevention of cancer through modification of lifestyle or environment exposures, and to understand the role of genetic factors in cancer risk.

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