Research Team:  Backman, Bergan, Catalona, Chatterton, Hendrick, Khan, Martini, Roy

Members of this diverse group of investigators (i.e., from radiology, oncology, surgery, obstectrics/gynecology, urology, gastroenterology or biomedical engineering) are conducting research to discover new ways for identifying early stage, more treatable, cancer lesions and novel biomarkers of risk and response to chemopreventive agents. This work expands the boundaries in molecular biology, genetics, and physics for developing new technologies and for refining existing proven technologies. Advanced studies of breast imaging (Hendricks, Channin) and ovarian cancer early detection methods (Schink) are ongoing, as are studies to refine the use of PSA for prostate cancer early detection (Catalona). Members of this group are developing state-of-the-art technologies to detect early stage alterations in colonic (Backman, Roy) or skin (Martini) epithelia using light scattering properties which permits identification of alterations without the need for biopsy. Novel methods of collecting biologic specimens for assessing local effects in breast tissue are being developed (Khan, Chatterton), as are robust method to profile gene expression in single cell populations present within intact tissue (Bergan).

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