Animal model systems for treatment or prevention

Research Team:  H. Band, V. Band, Bulun, Chakravarti, Chatterton, Clevenger, Cryns, Lupu

The translation of concepts from the laboratory to the clinic is facilitated by the examination of models of breast cancer in animals. Transgenic and knock-out mouse models have been developed by the group that will enable the in vivo assessment of the contribution of specific signaling proteins to the pathogenesis of breast cancer (H. Band, V. Band, Bulun, Chakravarti, Clevenger, Cryns, Lupu). In addition, xenografting of human breast cancer into athymic nude mice will further enable a direct assessment of the function of signaling proteins, but also enable the direct in vivo testing of newly developed pharmacologic agents (H.Band, V. Band, Bulun, Chatterton, Clevenger, Cryns, Lupu). The above models will enable the in vivo analysis of seminal events in the pathogenesis and progression of breast cancer including angiogenesis, metastasis, and drug resistance.

Previous Page