Stephen W Ranson Professor, Cell and Molecular Biology; Feinberg School of Medicine
TRIST-Prostate/Genitourinary Cancers,Tumor Invasion, Metastasis & Angiogenesis
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The intermediate filament (IF) network is utilized by cells to establish intracellular connections from the cell surface to the nucleus. Disruption of IF structures is associated with a large variety of disease states and aberrant IF expression is observed in many tumor cells. Dr. Goldman focuses on the structure and function of IF networks in normal and neoplastic fibroblasts and epithelial cells. This large family of proteins establishes networks throughout the cytoplasm and the nucleus. Recently, Dr. Goldman demonstrated that nuclear IFs (lamins) form a nucleoplasmic network that is involved in regulation of DNA replication. Because the IF system forms a dynamic network linking the nuclear and cell surfaces, additional studies are underway to examine the contribution of IFs to diverse cellular processes such as maintenance of cell shape, organelle movements, nuclear positioning, signal transduction and chromatin organization.