Professor, Medicine, Gastroenterology Division; Feinberg School of Medicine
Cancer Prevention,TRIST-Gastrointestinal Cancers
View Publications Listing
The Barrett lab investigates mechanisms of epithelial stem cell activation in mouse and human models of Inflammatory Bowel Disease (IBD). Areas of interest include studying the cooperation between phosphoinositide 3-kinase (PI3K) and Wnt in activating beta catenin signaling (He et al Nat Gen 2007). We find that intestinal inflammation increases PI3K-activated beta catenin in intestinal epithelial progenitor and stem cell populations. We propose that this pathway will be a novel target in strategies for chemoprevention (e.g. colitis-induced cancer). In all projects of the lab we strive to have strong translational components by testing lab-generated hypotheses in patient material.