Professor, Pediatrics; Feinberg School of Medicine
Tumor Invasion, Metastasis & Angiogenesis
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My research interests are in 2 areas: 1. Tissue-specific regulation of gene expression, chromatin structure and modification in the context of the CFTR gene, which when mutated causes the common inherited disease Cystic Fibrosis. We identified and are characterizing intronic and extragenic elements that control CFTR gene expression, modulate the 3D structure of the locus and mediate tissue specificity. More recently we extended these studies to the analysis of transcriptional networks that coordinate epithelial function genome wide
2. Pancreas Cancer. We are investigating the role of secreted proteoglycans (collagen XV and the MUC6 mucin) in initiation, invasion and metastasis of human pancreatic adenocarcinoma.