Associate Professor, Medicine, Endocrinology Division; Feinberg School of Medicine
Signal Transduction in Cancer
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Our laboratory is interested in understanding the mechanisms by which energy homeostasis is differencially regulated in males and females and how does this influence the risks of obesity and diabetes. We currently focus on identifying the cellular and molecular mechanisms by which estrogens and androgens program and regulate energy metabolism in a gender-specific manner. We use genetic, physiological, molecular, and pharmacological tools to study mice with conditional knockouts of the sex steroid receptors as well as cell culture models in highly controlled environments. Our goal is 1) to obtain a better understanding of the biological processes at the root of diabetes and obesity and the role of gender in this process 2) to determine whether modulating estrogen/androgen actions in a tissue-specific manner can have a therapeutic impact on diabetes and obesity.