Assistant Professor, Microbiology-Immunology; Feinberg School of Medicine
Tumor Invasion, Metastasis & Angiogenesis,TRIST-Gastrointestinal Cancers
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The goal of my laboratory is to determine the transcriptional regulation of intestinal immune responses. We have characterized the interactions between various transcription factors (e.g., ROR?t and Foxp3) involved in specifying development of Th17 cells and the related iTreg lineage and how they eventually determine whether the T cell adopts the Th17 or Treg cell fate. Recently, we have been focusing on the molecular regulation of ROR?t+ innate lymphoid cells by the aryl hydrocarbon receptor (Ahr), a ligand-dependent transcription factor under steady-state physiological conditions, during inflammation or autoimmunity. This work has implications for understanding how to modulate intestinal immune responses in different disease settings, may ultimately lead to identification of new therapeutic targets for human IBD or colon cancer.