Assistant Professor, Preventive Medicine; Feinberg School of Medicine
Cancer Cell Biology,Hematologic Malignancies
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Dr. Rosemary Braun is a computational systems biologist whose with an interest in modeling the emergence of complex phenotypes from the integrated molecular properties of cells. Her research focuses on the development of integrative analysis methods for high-throughput genomic data (including gene expression profiling, GWAS, and next-gen sequencing data). These methods share a common theme of taking a pathway perspective to elucidate biological systems (rather than single genes) that play a role in disease, and are designed to incorporate genomic, transcriptomic, and epigenetic data. Through interdisciplinary collaborations with cancer biologists and clinicians, Dr. Braun has applied these methods to elucidate pathways that contribute to prostate, breast, liver, and eosophageal cancer susceptibility, and is actively developing and applying computational methods to investigate the molecular basis of hematological cancers.