Professor, Molecular Biosciences; Judd A. and Marjorie Weinberg College of Arts and Sciences
Cancer and Physical Sciences
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Dr. Mondragon's work is concerned with the structure and fuction of macromolecules. In particular, he is interested in three broad areas: DNA topoisomerases, RNase P, and spectrin. His work on topoisomerases seeks to understand how this enzymes, a major therapeutic target, work at the atomic level. He is studying topoisomerases from bacteria, archaea and eukarya. Dr. Mondragon also works on the structure of a universally conserved ribozyme, RNase P. His structural work on this key ribozyme addresses the major differences between RNase P from different organisms. Finally, he is also studying the interactions of spectrin and ankyrin, two vital components of the red blood cell cytoskeleton.