Professor, Molecular Biosciences; Judd A. and Marjorie Weinberg College of Arts and Sciences
Cancer Cell Biology,Women's Cancer
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Research efforts in the Radhakrishnan lab are focused on understanding the molecular mechanisms of eukaryotic transcription regulation at multiple levels including sequence-specific DNA-binding, recruitment of coregulators, and assembly of multi-component nucleoprotein and chromatin-modifying complexes. Mis-regulated transcription characterizes the pathology of a variety of diseased states including many forms of cancer and clarifying the structural basis governing normal and aberrant macromolecular associations can lead to a better understanding of the regulatory mechanisms at a fundamental level.