Professor, Molecular Biosciences; Judd A. and Marjorie Weinberg College of Arts and Sciences
Cancer Cell Biology
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The goal of Dr. Rosenzweig's research program is to understand metalloprotein function on the molecular level by using X-ray crystallographic, biophysical, and biochemical techniques. Projects in her laboratory are divided into two areas, metal trafficking proteins and metalloenzymes, with an increasing focus on structural characterization of integral membrane proteins. In the metal trafficking area, she is focusing on the Wilson disease protein and homologs. Recently, this copper transporting ATPase has been shown to be upregulated in cells resistant to the anticancer drug cisplatin. She is working to understand how these ATPases bind and transport metal ions on the molecular level. In the metalloenzyme area, Dr. Rosenzweig is working on ribonucleotide reductase (RNR) from both yeast and E. coli. Her recent work on yeast RNR is particularly relevant since eucaryotic RNRs are a target for anticancer drugs.