The Transgenic and Targeted Mutagenesis Core Facility is a university-wide shared resource dedicated to generating genetically-modified animals for investigators within the research community at Northwestern University and its affiliate institutions. Transgenic and gene targeting technologies are used to generate animal models in which the complexities of gene function and regulation can be studied. The ability to either express or functionally inactivate, in genetically modified animals, defined genes in a developmentally- and tissue-specific manner has lead to significant insights into and the understanding of the role genes play under both normal and abnormal conditions in many different and diverse fields of scientific study.
- Pronuclear Microinjection/li>
- Generation of transgenic mice
- Transient transgenesis
- ES cell microinjection into Blastocysts
- Gene targeting
- ES cell targeting
- Generation of chimeric mice
- Rederivation of pathogen free mouse strains
- Cryopreservation of mouse embryos/sperm
- Recovery of cryopreserved mouse lines
Director:
Rajeshwar Awatramani, PhD
Director of Core Operations:
Lynn T. Doglio, PhD
l-doglio@northwestern.edu
Location(s):
Transgenic suite and Cryopreservation Laboratory
- Robert H. Lurie Research Center, 303 E. Superior, Chicago
ES cell Laboratory
- McGaw Paviillion,710 North Fairbanks Court, 8th floor, Chicago
Phone:
312.503.0088
Website:
http://www.cgm.northwestern.edu/cgm/Core-Facilities/Transgenic-and-Targeted-Mutagenesis-Core
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