Ishwar Radhakrishnan, PhD
Professor, Molecular Biosciences; Judd A. and Marjorie Weinberg College of Arts and Sciences
Research Program
- Associate Members
Cancer-Focused Research
The Radhakrishnan lab studies the molecular mechanisms of transcription regulation, specifically, how DNA-bound transcription factors recruit coactivators, nucleating protein-protein interaction networks that extend to the transcription machinery, and how chromatin-modifying complexes read, interpret, and modify the histone code. We are asking these questions in the context of (i) cAMP signaling mediated by CREB and its coactivators and (ii) a cohort of related, yet functionally distinct, histone deacetylase-associated chromatin-modifying complexes.