Northwestern University Feinberg School of Medicine
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Quantitative Data Sciences Core

The mission of the Quantitative Data Sciences Cores is to provide a state-of-the-art, integrated approach for data science support in Biostatistics, Bioinformatics and Clinical Informatics to Lurie Cancer Center members in the basic, clinical and population sciences.  The core combines the former Biostatistics Core Facility and the Cancer Informatics Core Facility and collaborates in three main areas: biostatistics, bioinformatics and clinical informatics.

Contact Us

Associate Directors

Denise ScholtensDenise M. Scholtens, PhD
Associate Director of Biostatistics
Professor, Preventive Medicine and Neurological Surgery

BlankMatthew J. Schipma, PhD
Associate Director of Bioinformatics
Research Assistant Professor, Biochemistry and Molecular Genetics

Firas WehbeFiras H. Wehbe, MD, PhD
Associate Professor, Preventive Medicine
Associate Director of Clinical Informatics

Locations

  • Biostatistics
    680 N. Lake Shore Drive, 1400
    Chicago, IL 60611
    312-503-2288 or 312-908-1970
  • Bioinformatics
    Rubloff Building, 11-144
    750 N. Lake Shore Drive
    Chicago, IL 60611
    312-503-5324
  • Clinical Informatics
    Rubloff Building, 11-166
    750 N. Lake Shore Drive
    Chicago IL 60611
    312-503-2311

Business Coordinator

General Email

 

Intake Form

Please fill out a brief Project Description Form when you are ready to submit your request for QDSC services, and a QDSC member will get in touch with you.

Services & Equipment

 Key Services

Biostatistics:

  • Research study design
    • Power/sample size
    • Experimental design
    • Statistical Analysis Plans
    • Data collection tools
  • Statistical analysis
    • Variety of statistical methods
    • Data visualization
    • Interpretation of results
    • Manuscript writing
  • Clinical Trials
    • Design and development
    • eCRF design with PI and QAM
    • Analysis and reporting
  • Grant development
  • Clinical trials support (IIT)
  • Basic science and clinical studies
  • Reproducible research pipelines

Bioinformatics:

  • Raw data from NUSea or outside data
  • NGSCheckMate — sample validation
  • RNA-Sea
    • Bulk or single cell
    • Alignment, transcript quantification, differential expression, pathway analysis
    • scRNA-Seq
  • ChIP-Sea
  • Variant Analysis
  • CRISPR screen analysis
  • ATAC-Sea
  • Standard pipelines and new pipeline development
    • CETO — modular system of sequence analysis tools and pipelines
  • Study design and analysis in collaboration with Biostatistics
Clinical Informatics:
  • OncoSET
    • Data management: outcomes registry, biobank, raw sequence files
    • Integration with Epic
  • Data Capture (NOT1S/REDCap)
    • Development
    • Work with QAM to standardize across trial
  • Analytics for LCC and CTO
    • Patient recruitment to trials
    • Financial tracking and dashboard
    • CCSG/CoC reports
    • LCC Membership DB
  • NM EDW
    • Clinical research data analysts
    • EHR data exports
  • Pathology Core
    • Biobanking database
    • Disburser — sample disbursing tracking
  • Custom clinical databases
    • Prostate, Head and Neck, Melanoma, RadOnc Breast, COVID-19 and Cancer

In addition to the co-directors, each area includes faculty and staff who will work with Lurie Cancer Center members in providing expertise as needed. Core members also engage in the following general activities:

  • Collaboration with cancer center members across all programs;
  • Collaboration with cancer center members on both the Chicago and Evanston campuses
  • Discussion about research objectives and hypotheses;
  • Writing informatics and statistical sections for grant applications;
  • Active collaboration through funded grant activity;
  • Active co-authoring of research findings
  • Interaction and integration with other cancer center cores as needed;
  • Interaction and integration but not overlapping with cores and entities external to the cancer center as needed (NUCATS, IPHAM, CPS, CDSI, BCC, NUGENE, NUSeq);
  • Development of new methodology in Biostatistics and Biomedical Analytics 
  • Development and review of cancer related protocols;
  • Education through individual contact, group seminars, journal clubs and fellow/junior faculty development;
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